MBIG_members

MetalloBiomolecule Interest Group (MBIG)

MBIG is kind of a namesake of MPIG (MetelloProtein Interest Group) at the University of Minnesota where I spent 3 years as a postdoc working on iron proteins (including Fe-superoxide dismutase, isopenicillin N synthase, purple acid phosphatases, and ribonucleotide reductase) and Fe complexes (including Fe-bleomycin and synthetic Fe complexes) in Professor Lawrence Que's group. To reflect the projects that we have been working on in the group, i.e., metalloproteins, metalloantibiotics, metallopeptides, metal-centered hydrolysis, and metal-DNA chemistry, the acronym MBIG (MetalloBiomolecule Interest Group) finally came out that everyone liked. Here is a list of the group members in the MBIG:

Current Members:
Justin Moses, Ph.D. Candidate, who was a recipient of an award from the East Asia and Pacific Summer Institutes EAPSI of the NSF, joining with the Nation Science Council of Taiwan, and went to Taiwan in Summer of 2010 working with Prof. Tung-Kung Wu at National Chiao Tung University, and has been exploring the serendipitos activities of dinuclear Streptomyces aminopeptidase and the antibiotic thiostrepton.

Christie Tang, Ph.D. student, who is working on inhibition of the oxidative activity of Cu(II)-β-Amyloid and interactions of biomolecules with metalloantibiotics by the use of NMR and kinetic methods

Cole Cerrato, Ph.D. student, who is working on interactions of biomolecules with metalloantibiotics and other metallobiomolecules by the use of NMR and kinetic methods

Former Graduate Students:
Xiangdong (David) Wei, Ph.D. (now at Washington Mutual, Chicago), “Two-Dimensional NMR Studies of Paramagnetic Metallo-Biomolecules: Metal-Antibiotic Drug Complexes and Protein Structure Determination”, 1996.
Awards:
Summer Fellowship, Institute for Biomolecular Science, USF (1994, 1995)
Departmental "Ashford Award" for outstanding graduate student (1995)
Publications:

Ming, L.-J.; Wei, X. "An Ytterbium(III) Complex of Daunomycin, a Model Metal Complex of Anthracycline Antibiotics" Inorg. Chem. 1994, 33, 4617-4618. (abstract 5)
Wei, X; Ming, L.-J.; Cannons, A. C.; Solomonson, L. P. "¹H and ¹³C NMR Studies of a Truncated Heme Domain from Chlorella vulgaris Nitrate Reductase: Signal Assignment of the Heme Moiety" Biochim. Biophys. Acta 1998, 1382, 129-136. (abstract 11)

Wei, X.; Ming, L.-J. "Comprehensive 2D ¹H NMR Studies of Paramagnetic Lanthanide(III) Complexes of Anthracycline Antitumor Antibiotics" Inorg. Chem. 1998, 37, 2255-2262. (abstract 12)

Wei, X.; Ming, L.-J.* "NMR Studies of Metal Complexes and DNA Binding of the Quinone-Containing Antibiotic Streptonigrin" J. Chem. Soc. Dalton Trans. 1998, 2793-2798. (abstract 15)

Jon Epperson, Ph.D., (postdoc at Department of Chemistry, Florida State University; Law degree at George Washington Universty; currently a high-tech patent lawyer at the US Patents Office) “Paramagnetic Cobalt(II) as a Nuclear Magnetic Resonance Probe for the Study of Metallo-Macromolecules: from Peptides and Proteins to Dendrimers”, 1999.
Awards:
Summer Fellowship, Institute for Biomolecular Science, USF (1994, 1995)
USF Graduate Council Outstanding Dissertation Award (2000)
Publications:

Epperson, J. D.; Ming, L.-J.; Woosley, B. D.; Baker, G. R.; Newkome, G. R. "Analyzing the Infrastructure of Dendritic Macromolecules Using a Paramagnetic Metal Ion NMR Probe" Inorganic Chemistry 1999, 38, 4498-4502. (abstract 19)

Epperson, J. D.; Ming, L.-J. "Proton NMR Studies of Co(II) Complexes of Bacitracin Analogous —Insight into Structure-Activity Relationship" Biochemistry 2000, 39, 4037–4045. (abstract 23)

Epperson, J. D.; Ming, L.-J. "Binding of Cobalt(II) and Copper(II) to Trinuclear Phospholipase C from Bacillus cereus— A Novel ¹H NMR Spectrum of a “Tri-Cu(II)” Center in Protein" J. Inorg. Biochem. 2001, 87, 149-156. ( abstract 27)

Epperson, J. D.; Ming, L.-J.; Baker, G. R.; Newkome, G. R. "Paramagnetic Cobalt(II) as an NMR Probe for Dendrimer Structure, Mobility, and Coorperativity" J. Am. Chem. Soc. 2001, 123, 8583–8592. (abstract 28)

Ming, L.-J.; Epperson, J. D. "Metal Binding and Structure–Activity Relationship of the Metalloantibiotic Peptide Bacitracin" J. Inorg. Biochem. (a focused review) 2002, 91, 46–58 (abstract 30)

Tay, W. M.; Epperson, J. D.; da Silva, G. F. Z.; Ming, L.-J. “¹H NMR, Mechanism, and Mononuclear Oxidative Activity of the Antibiotic Metallopeptide Bacitracin: The Role of D-Glu-4, Interaction with Pyrophosphate Moiety, DNA Binding and Cleavage, and Bioactivity” J. Am. Chem. Soc. 2010, 132, 5652–5661. (Abstract)

Hyun Ik Park, Ph.D. (was an NSF postdoctoral fellow and an American Heart Association Postdoctoral Fellow at the Department of Chemistry of Florida State University, currently at R&D Systems in Minneapolis ), “The Mechanistic Studies of Mononuclear and Dinuclear Metalloproteases, Astacin and Aminopeptidase”, 1999.
Awards:
Outstanding Student Presentation Award, ACS Annual Meeting of the Florida Section, 1995
Summer Fellowship, Institute for Biomolecular Science, USF (1995)
Departmental "Ashford Award" for outstanding graduate student (1999)
Departmental "Tharp Publication Award" (1999)
Publications:

Lin, L.-Y.; Park, H. I.; Ming, L.-J. "Metal Binding and Active Site Structure of Di-Zinc Streptomyces griseus Aminopeptidase" J. Biol. Inorg. Chem. 1997, 2, 744-749. (abstract 10)

Park, H. I.; Ming, L.-J. "The Mechanistic Role of the Coordinated Tyr in Astacin" J. Inorg. Biochem. 1998, 72, 57-62. (abstract 16)
Park, H. I.; Ming, L.-J. "A Novel 10¹⁰ Rate Enhancement of Phosphodiester Hydrolysis by a Di-Zinc Aminopeptidase– Transition State Analogues as Substrates?" Angew. Chem. Intl. Engl. Ed. 1999, 38, 2914-2916. (abstract 21)

Hasselgren, C.; Park, H. I.; Ming, L.-J. "Metal Ion Binding and Activation of Streptomyces griseus Aminopeptidase —Cadmium(II) Binding as a Model" J. Biol. Inorg. Chem. 2001, 6, 120–127. (abstract 24)

Ercan, A.; Park, H. I.; Ming, L.-J. "Remarkable Enhancement of the Hydrolyses of Phosphoesters by Dimetal Centers —Streptomyces Aminopeptidase as a “Natural Model System”" Chem. Commun. 2000, 2501–2502. (abstract 25)

Park, H. I.; Ming, L.-J. "Mechanistic Studies of the Astacin-like Serratia Metalloendopeptidase Serralysin —Highly Active (>2,000%) Co(II)- and Cu(II)-Substituted Derivatives for Further Corroboration of a 'Metallotriad' Mechanism" J. Biol. Inorg. Chem. 2002, 7, 600–610. (abstract 29)

Ercan, A.; Park. H. I.; Ming, L.-J. “A ‘Moonlighting’ Di-Zinc Aminopeptidase from Streptomyces griseus: Mechanisms for Peptide Hydrolysis and the 4 × 10¹⁰-Fold Acceleration of the Alternative Phosphodiester Hydrolysis” Biochemistry 2006, 45, 13779–13793. (abstract 40)

Jason Palcic, Ph. D. (postdoctoral reserach/lecturer at the Department of Chemistry, University of Memphis and is now the Chemical Terrarism Coordinator at the Florida Department of Health), who was working on then very competitive and challenging 2D NMR techniques for the study of paramagnetic mitramycin-Co(II)-DNA complexes which exhibit "high resolution" hyperfine-shifted ¹H NMR spectra, and on P-31 NMR study of nitrate reductase; “Proton and Phosphorus NMR Studies of Paramagnetic Metallo-Biomolecules: from Metalloantibiotics to Metalloenzymes”, 2000.
Publications:

Palcic, J. D.; Ming, L.-J.; Barber, M. J. “³¹P NMR Spectroscopy of the Flavin Domain of Assimilatory Nitrate Reductase” in preparation

Palcic, J. D.; Ming, L.-J. "'High Resolution" ¹H NMR Study of Paramagnetic Metallobiomolecules: Mithramycin-Co(II)-DNA ternary complex as an Example" in preparation

Craig Bertolucci, Ph. D. (did postdoctoral research at the Department of Biochemistry, the Ohio State University and at the St. Jude Children's Hospital; Currently an instructor at Kennesaw State University), “¹H Nuclear Magnetic Resonance Investigations of the Paramagnetic Derivatives of the Metalloproteins Parvalbumin, FixL, and Aminopeptidase”, 2001.
Awards:
Summer Fellowship, Institute for Biomolecular Science, USF (1995)
Departmental "Outstanding First-Year Graduate Student" Award (1994)
Departmental "Ashford Award" for outstanding graduate student (1997)
Publications:

Bertolucci, C.; Ming, L.-J.; Gonzalez, G.; Gilles-Gonzalez, M. A. "Assignment of the Hyperfine-Shifted ¹H NMR Signals of the Heme in the Oxygen Sensor FixL from Rhizobium metiloti" Chem. Biol. 1996, 3, 561-566. (abstract 8)

Harris, M. N.; Bertolucci, C. M.; Ming, L.-J. "Paramagnetic Cobalt(II) as a Probe for Kinetic and NMR Relaxation Studies of Phosphate Binding and Catalytic Mechanism of Streptomyces Dinuclear Aminopeptidase" Inorganic Chemistry 2002, 41, 5582-5588. (abstract 31)

Michael Harris, Ph.D. (did postdoctoral research at the University of New Mexico and is now a postdoc/research chemist at the Los Alamos National Laboratory) “Mechanistic and Structural Studies of Aminopeptidase from Streptomyces griseus and Prolyl Oligopeptidase from Pyrococcus furiosus”, 2001.
Award:
Departmental "Tharp Publication Award" (2000)
Publications:

Harris, M. N.; Ming, L.-J. "Different Phosphate Binding Modes of Streptomyces griseus Aminopeptidase between Crystal and Solution States and the Status of Zinc-Bound Water" FEBS Lett. 1999, 455, 321-324. (abstract 22)

Harris, M. N.; Madura, J. D.; Ming, L.-J.; Harwood, V. J. "Kinetic and Mechanistic Studies of Prolyl Oligopeptidase from the Hyperthermophile Pyrococcus furiosus" J. Biol. Chem. 2001, 276 , 19310–19317. (abstract 26)

Altan Ercan, Ph.D. (Did postdoctoral research at the Department of Biochemistry and Molecular Biology of the University of Oklahoma and Scripps–Florida, and Harvard Medical school; currently a research assistant professor at Massachusetts General Hospital and Harvard Medical School) “Mechanistic Investigation of Dinuclear Peptidases from Streptomyces griseus and Alteromonas sp. Prolidase: Transition-State Analogues as Probes”, 2003.
Award:
Departmental "Tharp Publication Award"
Publications:

Ercan, A.; Park, H. I.; Ming, L.-J. "Remarkable Enhancement of the Hydrolyses of Phosphoesters by Dimetal Centers —Streptomyces Aminopeptidase as a “Natural Model System”" Chem. Commun. 2000, 2501–2502. (abstract 25)

Lykourinou-Tibbs, V.; Ercan, A.; Ming, L.-J. “Iron(III)-Chelex Resin Complex as a Prototypical Heterogeneous Catalyst for Phosphoester Hydrolysis” Catal. Commun. 2003, 4, 549–553. (abstract 33)

Ercan, A.; Tay, W. M.; Grossman, S. H.; Ming, L.-J. “The Role of Metal Ions in Peptide Hydrolysis and the 7 × 10¹⁰-Fold Rate Enhancement of Phosphodiester Hydrolysis by Dinuclear Streptomyces Aminopeptidase” J. Inorg. Biochem. 2010, 104, 19–29. (Abstract)

Vasiliki Lykourinou, Ph.D. (was an instructor at the University of South Florida; currently an instructor at Northeastern University) “Copper and Iron Complexes of Linear and Cross-linked Polymers as Catalysts for phosphoester Hydrolysis and Oxidative Transformation of Phenolic and Catecholic Substrates” 2006.
Award:
Departmental Alexious Award, 2005
Publications:

Hanafy, A. I.; Lykourinou-Tibbs, V.; Bisht, K. S. Ming, L.-J. “Effective Heterogeneous Hydrolysis of Phosphodiester by Pyridine-Containing Metallopolymers” Inorg. Chim. Acta. 2005, 358, 1247–1252. (abstract 34)

Lykourinou, V.; Hanafy, A. I.; da Silva, G. F. Z.; Bisht, K. S.; Larsen, R. W.; Livingston, B. T.; Angerhofer, A.; Ming, L.-J. “How Well Should the Active Site and the Specific Recognition Be Defined for Proficient Catalyses? —Effective and Cooperative Polyphenol/Catechol Oxidation and Oxidative DNA Cleavage by a Copper(II)-Binding and H-bonding Copolymer” Eur. J. Inorg. Chem. 2008, 2584–2592. (abstract)

da Silva, G. F. Z.; Lykourinou, V.; Angerhofer, A.; Ming L.-J. “Rectification of the Roles of Methionine-35 and Reducing Agents in Metal-Centered Oxidation Chemistry of Copper(II)-β-Amyloid with Kinetics and EPR Spectroscopy” BBA–Molecular Basis of Diseases. 2009, 1792, 49–55. (abstract)

Lykourinou, V.; Hanafy, A. I.; Angerhofer, A.; Bisht, K. S.; Ming, L.-J. “Iron(III)-Polymers as Proficient Catalysts for Acid Hydrolysis of Phosphodiester and Oxidative DNA Cleavage—Insight into Rational Design of Functional Metallopolymers” Eur. J. Inorg. Chem. 2009, 1199–1207.

Wang, L.; Ye, Y.; Lykourinou, V.; Angerhofer, A.; Ming, L.-J.; Zhao, Y. “Metal Complexes of a Multidentate Cyclophosphazene with Imidazole-Containing Side Chains for Hydrolyses of Phosphoesters: Bimolecular versus Intramolecular Dinuclear Pathways” Eur. J. Inorg. Chem. 2011, 674–682. (Abstract)

Lykourinou, V.^$; Chen, Y.^$; Wang, X.-S.; Meng, L.; Hoang, T.; Ming, L.-J.; Musselman, R. L.; Ma, S. “Immobilization of MP-11 into a Mesoporous Metal–Organic Framework, MP-11@mesoMOF: A New Platform for Enzymatic Catalysis” J. Am. Chem. Soc. 2011, 133, 10382–10385. (abstract) ^$These authors contributed equally.

Chen, Y.; Lykourinou, V.; Vetromile, C.; Hoang, T.; Ming, L.-J.; Larsen, R.; Ma, S. “How Can Proteins Enter the Interior of a MOF? Investigation of Cytochrome c Translocation into a MOF Consisting of Mesoporous Cages with Microporous Windows” J. Am. Chem. Soc. 2012, 134, 13188–13191. (abstract)

Chen, Y.; Lykourinou, V.; Hoang, T.; Ming, L.-J.; Ma, S. “Size-Selective Biocatalysis of Myoglobin Immobilized into a Mesoporous Metal-Organic Framework with Hierarchical Pore Sizes” Inorg. Chem. 2012, 51, 9156–9158. (abstract)

Lykourinou, V.; Ming, L.-J. “Metalloproteins and Metallopeptides—Natural Metallofoldamers” in Metallofoldamers: Supramolecular Architectures from Helicates to Biomimetics, Chapter 1, PP. 1–50, Maayan, G.; Albrecht, M. Eds. Wiley, 2013. (Table of Contents of the book) (excerpt from Google Books) (book excerpt from the publisher).

Lykourinou, V.; Ming, L.-J. “Mechanistic Insights into Phenol Oxidation by a Copper(II) Complex of a Pyridine/Amide-Containing Copolymer in an Aqueous Medium” Eur. J. Inorg. Chem. 2015, 2015, 375–381. (This paper has been selected by the editor to feature on the cover and in the cover profile of the issue. http://onlinelibrary.wiley.com/doi/10.1002/ejic.v2015.3/issuetoc) (abstract and reprint).

    Giordano F. Z. da Silva, Ph.D. (Did postdoctoral research at the University of Texas Health Science Center in Houston and Rice University with Prof. Graham Palmer on EPR; currently a research assistant professor at University of Texas Health Science Center at Houston) “The Bioinorganic Chemistry Of Copper-Containing Systems: From Type-3 Systems Pertinent To Alzheimer’s Disease To Mononuclear Hydrolysis Involved In Biological Development” 2007.
    Awards:
The Departmental Ashford Award, 2006, the Departmental George Bursa Award, 2006, and a University Successful Latino Student Award, 2006. NIH Postdoctoral Fellowship
    Publications:

da Silva, G. F. Z.; Tay, W. M.; Ming, L.-J. “Catechol Oxidase-Like Oxidation Chemistry of the 1–20 and 1–16 Fragments of Alzheimer’s Disease-Related β-Amyloid Peptide: Their Structure-Activity Correlation and the Fate of Hydrogen Peroxide” J. Biol. Chem. 2005, 280, 16601-16609. (abstract 35)

da Silva, G. F. Z.; Ming, L.-J. “Alzheimer’s Disease-Related Copper(II)-β-Amyloid Peptide Exhibits Phenol Monooxygenase and Catechol Oxidase Activities” Angew. Chem. Int. Ed. 2005, 44, 5501–5504. (Accepted without alterations). (abstract 37)

da Silva, G. F. Z.; Ming, L.-J. “Catechol Oxidase Activity of Di-Cu²⁺-Substituted Aminopeptidase from Streptomyces griseus” J. Am. Chem. Soc. 2005, 127, 16380-16381. (abstract 38)

da Silva, G. F. Z.; Reuille, R. L.; Ming, L.-J.; Livingston, B. T. “Overexpression and mechanistic characterization of blastula protease 10, a metalloprotease involved in sea urchin embyogenesis and development” J. Biol. Chem. 2006, 281, 10737–10744. (abstract 39)

da Silva, G. F. Z.; Ming, L.-J. “‘Metallo-ROS’ in Alzheimer’s Disease: Metal-Centered Oxidation of Neurotransmitters by Cu^II-β-Amyloid Provides an Alternative Perspective for the Neuropathology of Alzheimer’s Disease” Angew. Chem. Int. Ed., 2007, 46, 3337-3341. (abstract)

Tay, W. M.; da Silva, G. F. Z.; Ming L.-J. “Metal Binding of Flavonoids and Their Distinct Inhibition Mechanisms toward the Oxidation Activity of Cu²⁺–β-Amyloid—Not Just Serving as Suicide Antioxidants!” Inorg. Chem. 2013, 52 (2), 679–690. (abstract) Dedicated to Professor Bertini (1940–2012): In memory of Professor Ivano Bertini, whose “paramagnetic NMR” explorations enlightened our research endeavors.

William M. Tay, Ph.D. (Did postdoctoral research at Mayo Clinic, Jacksonville and University of Illinois at Chicago; currently a chemist at a pharmaceutical company) “Metallopeptides As Model Systems For The Study Of Cu(II)-Dependent Oxidation Chemistry” 2008.
Publications:

Tay, W. M.; Hanafy, A. I.; Angerhofer, A.; Ming, L.-J. “Metal Binding of Histatin 5 and Oxidative Activity of Its Copper Complex—A Possible Role of Salivary Copper in Antimicrobial Activity” Bioorg. Med. Chem. Lett. 2009, 6709–6712. (Abstract)

Le Wang, Ph.D. (She is now an instructor at Shanghai University of Engineering Science.) “Design, Synthesis, and Enzyme Mimetics of Metal Complexes of Novel Multidentate-Containing Cyclophosphazene Ligands” 2010, a co-directed student from Zhengzhou University, China.
Publications:

Hashim, A.; Wang, L.; Juneja, K.; Ye, Y.; Zhao, Y.; Ming, L.-J. “Vitamin B6s Inhibit Oxidative Stress Caused by Alzheimer’s Disease-Related Cu^II-β-Amyloid Complexes—Cooperative Action of Phospho-Moiety” Bioorg. Med. Chem. Lett. 2011, 21, 6430–6432. (abstract)

Alaa Hashim, Ph.D. (She is now an instructor at the University of Central Florida.) “Metallopeptides From Design to Catalysis: Structure, Oxidative Activities, And Inhibition Studies Of Designed And Naturally Occurring Metallopeptides” 2014
Publications:

M.S. Students

Hong-Chu Yang (went to Emory University pursuing Ph.D.), worked on NMR study of Yb(III)-substituted parvalmunin.

Lung-Yu (Victor) Lin, M.S. (now at Unilever, Taiwan), “Di-Zinc Aminopeptidase from Streptomyces griseus, a new Member of Dinuclear Metalloprotease”, 1996
Publication:

Lin, L.-Y.; Park, H. I.; Ming, L.-J. "Metal Binding and Active Site Structure of Di-Zinc Streptomyces griseus Aminopeptidase" J. Biol. Inorg. Chem. 1997, 2, 744-749. (abstract 10)

Kashmir Singh Juneja, M.S. (now is diligently taking care of a family business) “Tyrosinase-like Activity of Several Alzheimer’s Disease Related and Model Peptides and their Inhibition by Natural Antioxidants”, 2006
Publication:

Chien-Yi Wu, “Ni(II) as a Probe for Mechanistic Study of the aminopeptidase from Streptomyces griseus”, 2006–2008, incomplete, took an industrial position and is now a manager of an art gallery.

William J. Wagner, M.S. “Two Methodologies in Pursuit of the Elucidation of Copper (II)-Centered Bioinorganic Chemistry”, 2009

Visiting Students/Scholars
Catrin Hasselgren 1996; (Completed her Ph.D. at the Department of Inorganic Chemistry, Chalmers University of Technology, Sweden, 2002, and was a postdoctoral researcher at AstraZeneca in Sweden) worked on Cd(II) binding and activation of Streptomyces griseus Aminopeptidase.
Publication:
Hasselgren, C.; Park, H. I.; Ming, L.-J. "Metal Ion Binding and Activation of Streptomyces griseus Aminopeptidase —Cadmium(II) Binding as a Model" J. Biol. Inorg. Chem. 2001, 6, 120–127. (abstract 25)

Ahmed Hanafy, Ph.D. (from Egypt; 2001–2003; 2007), who was working on the hydrolytic and oxidative activities of Cu-binding polymers.

Le Wang (2009–2010), a visiting student from Zhengzhou University, China.

Former Undergraduate students
Students with thesis:
Catrin Hasselgren, (Completed her Ph.D. at the Department of Inorganic Chemistry, Chalmers University of Technology, Sweden, 2002 and is now a postdoctoral researcher at AstraZeneca in Sweden) worked on Cd(II) binding and activation of Streptomyces griseus Aminopeptidase, 1997.
Publication:
Hasselgren, C.; Park, H. I.; Ming, L.-J. "Metal Ion Binding and Activation of Streptomyces griseus Aminopeptidase —Cadmium(II) Binding as a Model" J. Biol. Inorg. Chem. 2001, 6, 120–127. (abstract 25)

Rosemary Keene (went the medical school at USF), studied and contributed to "Phosphate inhibition of Streptomyces griseus Aminopeptidase (abstract 22)" as her honors thesis project: “Kinetic and Metal Binding Studies of Zinc(II) and Cobalt(II) with Streptomyces griseus Aminopeptidase”, 1998.

Kashmir Junaja (Completed MA in Chemistry in 3 years, and continued the graduate program here) “Synthetic Metallohydrolases: Hydrolysis of Phosphodiesters by Iron (III) Complexes of 4-Vinylpyridine Methylmethacrylate Investigated with Kinetic and Thermodynamic Methods”, 2004.

Regina Maldonado, “Metal-Centered Catalysis: Saturation Kinetics and Thermodynamics of BNPP Hydrolysis by Fe(III) Complex of 2-Vinylpyridine-Acrylamide Copolymer” 2005.

Grant Barlow-Rademeyer, “Oxidation/oxygenation Catalysis by Copper Metallopolymers” 2006.

Morgan Courty, “Kinetic Characterization of Cu(II)-(Vinylpyridine-co-Styrene) polymer in polyphenol Oxidation”, 2006.

Irene M. Hotalen (went to the medical school here) “The Oxidative Properties of Manganese and its Applications to Pathology”, 2007.

Juliane Krueger, “Polyphenol Oxidase Activity in Context with a Copper(II) and 4-Vinylpyridine co-Styrene Polymer Complex”, 2008.

John C. O’Leary III (earned BA in performing arts and went to the Molecular Medicine PhD program here) “Inhibition of Prolidase by Cardiotoxic Anticancer Drugs”, 2008.

Christopher Corcoran (joined the PhD in Chemistry at the University of Illinois at Urbana-Champagne) “An investigation of metallopolymer-based biomimetic systems for catechol dioxygenases”, 2008.

Navin N. Singh (went to a medical school) “Copper Metallopolymer Oxidative Characteristics and Applications to the Study of Oxidative Diseases”, 2011

Sibel Demirel (went to a medical school) “Mechanistic Studies of the Catalytic Activities of Cu (II)-Bound Copolymers—Oxidative DNA Cleavage and Antioxidant Activities of Natural Products”, 2011

Undergraduate students without thesis:
Yohji Fukazawa (1994), Jurgen Thias (1995), Thu Luu (1996) a University Minority Scholar, Vasiliki Likourinou (1999/2000), Syed Hussain (2000); Vinh Phan (2001), Giordano da Silva (2001/2002), Jennifer Wellborn Brillant (2003), Rani Dadlani (2003), Dieu Thu Thi Nguyen (2003) a University Minority Scholar, Elizabeth Villarroel (2003/2004), Juamana Aram (2006), Kyle Burton, Justin Moses, Darrell Cole Cerrato, John Williams, Elizabeth D’Esposito, Erin Fagan, Maria Gomez, Daniel Leyva, Ruben Durand, Stephanie Yates, Benjamin Mehanni, Mrunal Tailor, Solianna Herrera, Aves Bukhari, Linda Vang (NSF-Seeds REU, 2013), Patrick McKeny, Miles White, Yuya Burkhart, Sy-Woei Hao, Kate-Lin Tran, Kim An Pham, Hieu Diep, Thu Suong Le, (There are many more I do not recall and lost record of, and hope one day I’ll learn that they are doing successfully!)

Former high school students in the Summer BioMed Program who worked in the lab:
1992
Kattron Rodes, East Bay High (parvalbumin purification)

1993
Ingrid Lim, Hillsborough High (purification of blue copper protein from spinach leaves)
Mandeep Dhala, Zephyrhills High (purification of blue copper protein from spinach leaves)

1994
Shanti Singh, Gaither HS (protein purification)
Katherine Lowther, Lake 'O Lake HS (protein purification)
Joe Thomas, Carninal Mooney HS (protein purification)

1995
Victor Chang, Jesuit High (protein purification)
Katherine Frost, Leto High (protein purification)
Pei-Jen Hwang, Tampa Bay Tech (protein purification)

1996
Pavan Cheruvu, Hillsborough High (metal activation of serralysin) He won the second place at the County Science Fair and the sixth place at state competition on inhibition study of Streptomyces aminopeptidase.
Reena Ninan, King HS (metal activation of serralysin)

1997
Jashleen Bedi (metal influence on aminopeptidase activity)

1998
Becky Konnerth, Andrew Kuo, Akshata Marballi, and Michelle Ming (inhibition study of aminopeptidase, and were acknowledged in the publication Harris, M. N.; Ming, L.-J. "Different Phosphate Binding Modes of Streptomyces griseus Aminopeptidase between Crystal and Solution States and the Status of Zinc-Bound Water" FEBS Lett. 1999 , 455, 321-324. abstract 22)

1999
Mary Chen, King HS (Inhibition Studies of Metalloaminopeptidase)

2000
Mary Chen (Inhibition of Metalloaminopeptidase by the Antibiotic Bacitracin—Alternative Biological Activity of Bacitracin?)
Ashwini Momarla (Hydrolytic Reactions by Metallobacitracin—Alternative Biological Activity of Metalloantibiotics?)

2002
Aswini Komarla, Anupama Kotha, Kara Brown, and Jane Zhu (involved in initial research on metallopolymer chemistry, and were acknowledged in: Hanafy, A. I.; Lykourinou-Tibbs, V.; Bisht, K. S. Ming, L.-J. “Effective Heterogeneous Hydrolysis of Phosphodiester by Pyridine-Containing Metallopolymers” Inorg. Chim. Acta. 2005, 358, 1247–1252. abstract )