INORGANIC CHEMISTRY 1994, 33, 4617-4618
An Ytterbium(III) Complex of Daunomycin, a Model Metal Complex of Anthracycline Antibiotics
Li-June Ming* and Xiangdong Wei
Department of Chemistry and Institute for
The activity and toxicity of the anthracycline antibiotics are due to their redox activity, DNA and phospholipid binding capabilities, and metal affinities. We report here the study of metal-anthracycline interactions using paramagnetic Yb3+ as a probe; a 1:1 Yb3+-daunomycin complex was prepared with its isotropically shifted H-1 NMR features fully assigned using 2D NMR techniques. This study provides the means for future study of the role of metal ions in anthacycline-biomolecule interactions.
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