Kinetic and Mechanistic Studies of Prolyl Oligopeptidase from the Hyperthermophile  Pyrococcus furiosus
Journal of Biological Chemistry 2001, accepted for publication

Michael N. Harris1, Jeffry D. Madura3, Li-June Ming*1, Valerie J. Harwood*2

1 Department of Chemistry and Institute for Biomolecular Science, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620
2 Department of Biology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620
3 Department of Chemistry and Biochemistry, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282-1530

Structure of Pfu POP (green ribbon representation) superimposed on the porcine POP (1qfs.pdb; red string representation). The porcine POP inhibitor (Z-Pro-prolinal) is represented as a multicolored thick bond representation. For clarity the N-terminal residues 1 - 23 are omitted from the porcine structure.